Tigecycline-d9 is a deuterium labeled form of Tigecycline, a broad-spectrum glycylcycline antibiotic. Tigecycline has a mean inhibitory concentration (MIC) for E. coli (MG1655 strain) of approximately 125 ng/mL. For Acinetobacter baumannii, the MIC50 and MIC90 are 1 and 2 mg/L, respectively. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules as tracers during drug development and can influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Broad-spectrum glycylcycline antibiotic
- Used as a tracer for quantitation during drug development
- Potential to influence pharmacokinetic and metabolic profiles